The eastern route ran high in the puna and mountain valleys from Quito, Ecuador to Mendoza, Argentina. The western route followed the coastal plain except in coastal deserts where it hugged the foothills. More than twenty routes ran over the western mountains, while others traversed the eastern cordillera in the mountains and lowlands. Some of these roads reach heights of over 5,000 metres (16,000 ft) above sea level. The trails connected the regions of the Inca empire from the northern provincial capital in Quito, Ecuador past the modern city of Santiago, Chile in the south. The Inca road system linked together about 40,000 kilometres (25,000 mi) of roadway and provided access to over 3,000,000 square kilometres (1,200,000 sq mi) of territory.

Situated between 500 to 800 metres (1,600 to 2,600 ft) above sea level, this monumental road, which could reach 20 metres (66 ft) in width, connected populated areas, administrative centers, agricultural and mining zones as well as ceremonial centers and sacred spaces.

These roads provided easy, reliable and quick routes for the Empire's civilian and military communications, personnel movement, and logistical support. The prime users were imperial soldiers, porters and llama caravans, along with the nobility and individuals on official duty. Permission was required before others could walk along the roads, and tolls were charged at some bridges. Although the Inca roads varied greatly in scale, construction, and appearance, for the most part they varied between about 1 to 4 metres (3.3 to 13 ft) in width.

Much of the system was the result of the Incas claiming exclusive right over numerous traditional routes, some of which had been built centuries earlier. Many new sections were built or upgraded substantially: through Chile's Atacama desert, and along the western margin of Lake Titicaca, serve as two examples.

The Qhapaq Ñan (English: Great Inca Road, or Main Andean Road, and meaning "the beautiful road") constituted the principal north-south highway of the Inca Empire traveling 6,000 kilometres (3,700 mi) along the spine of the Andes.

The Qhapaq Ñan unified this immense and heterogeneous empire through a well-organized political system of power. It allowed the Inca to control his Empire and to send troops as needed from the capital, Cusco.

The most important Inca road was the Camino Real, as it is known in Spanish, with a length of 5,200 kilometres (3,200 mi)). It began in Quito, Ecuador, passed through Cusco, and ended in what is now Tucumán, Argentina. The Camino Real traversed the mountain ranges of the Andes, with peak altitudes of more than 5,000 m (16,000 ft). El Camino de la Costa, the coastal trail, with a length of 4,000 kilometres (2,500 mi), ran parallel to the sea and was linked with the Camino Real by many smaller routes.